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Leptospirosis PCR testing provides rapid molecular detection of pathogenic Leptospira species, the causative agents of this significant zoonotic bacterial disease. This test identifies bacterial DNA in blood, urine, or tissue samples, enabling early diagnosis before antibody development and during antibiotic treatment, which is critical for this potentially fatal disease that can affect both animals and humans.
Early Infection DetectionZoonotic Pathogen IdentificationMulti-Sample Type CompatibilityTreatment-Stage Testing CapabilitySerovar Differentiation Potential.png)
Leptospirosis is caused by spirochete bacteria of the genus Leptospira with numerous pathogenic serovars affecting dogs, other animals, and humans. Transmission occurs through contact with infected urine or contaminated water, with the bacteria entering through mucous membranes or skin wounds. The disease can range from subclinical to severe, potentially causing acute kidney injury, hepatic dysfunction, pulmonary hemorrhage, and disseminated intravascular coagulation. PCR testing is particularly valuable during the first 10 days of infection (before antibody development) and can detect leptospires in blood during early infection and in urine during later stages, even after antibiotic administration has begun.
Clinical Significance of Leptospirosis PCR Testing
Zoonotic Risk: Critical for public health considerations and infection control.
Treatment Window: Early detection enables timely antibiotic intervention.
Pre-Antibody Detection: Diagnosis possible before seroconversion occurs.
Environmental Factors: Important consideration in regions with increasing prevalence.
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